Material Safety Data Sheet: Tert-Butyl Bromoacetate

1. Identification

Product Name: Tert-Butyl Bromoacetate
CAS Number: 5292-43-3
Synonyms: t-Butyl bromoacetate, 2-Bromoacetic acid tert-butyl ester
Recommended Use: Laboratory chemical, research and development, chemical intermediate
Supplier Information: Available from chemical supply companies; each supplier maintains emergency phone numbers and contact details
Emergency Phone Number: Refer to chemical supplier's 24-hour emergency contact

2. Hazard Identification

Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, eye irritation, environmental hazard
Label Elements: Pictograms: Skull and crossbones, exclamation mark, aquatic hazard
Signal Word: Danger
Hazard Statements: Toxic if swallowed, causes skin and eye irritation, may cause respiratory irritation, harmful to aquatic life
Precautionary Statements: Avoid contact with skin and eyes, wash hands thoroughly after handling, do not eat or drink while using, avoid release to the environment

3. Composition / Information on Ingredients

Chemical Name: Tert-Butyl Bromoacetate
CAS Number: 5292-43-3
Formula: C6H11BrO2
Molecular Weight: 195.06 g/mol
Concentration: 97-100% (as supplied)
Impurities: Trace organic byproducts or residual solvents possible depending on source

4. First Aid Measures

Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms persist; if breathing difficulties arise, call medical services immediately
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water for at least 15 minutes, seek medical advice if irritation continues
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing and get medical help
Ingestion: Do not induce vomiting, rinse mouth with water, get immediate medical attention
Notes to Physician: Treat symptoms; monitor for delayed reactions

5. Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray for larger fires
Hazards from Combustion: Formation of toxic gases including hydrogen bromide, carbon monoxide, carbon dioxide
Special Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear, approach from upwind
Firefighting Instructions: Cool exposed containers with water, avoid inhaling fumes, evacuate downwind area

6. Accidental Release Measures

Personal Precautions: Use personal protective equipment, avoid inhalation of vapors, ventilate area
Environmental Precautions: Prevent further leakage or spillage, stop material from entering drains or waterways
Methods for Cleanup: Absorb with inert material such as sand, transfer to suitable container for disposal, wash spill site after cleanup
Decontamination Approach: Wash with plenty of water and detergent; monitor for solvent residues

7. Handling and Storage

Precautions for Safe Handling: Avoid breathing vapors, prevent contact with skin, eyes, and clothing, handle in well-ventilated area or fume hood
Storage Conditions: Store in tightly sealed container, cool, dry, well-ventilated area, protect from light, store away from incompatible materials such as strong bases and oxidizing agents
Incompatibles: Alkalis, strong oxidizers, moisture
Specific Use: For laboratory or industrial use only

8. Exposure Controls and Personal Protection

Occupational Exposure Limits: No established occupational exposure limits (check SDS provided by your supplier for region-specific data)
Engineering Controls: Use fume hood, ensure mechanical exhaust or local ventilation
Personal Protective Equipment (PPE): Safety goggles, chemical-resistant gloves (nitrile or neoprene recommended), lab coat, respiratory protection if ventilation is inadequate
Hygiene Measures: Wash hands before breaks and at end of work, remove and wash contaminated clothing

9. Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Characteristic, slightly fruity
Odor Threshold: Not established
pH: Not applicable
Melting Point: -12 °C
Boiling Point: 154-155°C
Flash Point: 64°C (closed cup)
Evaporation Rate: Not determined
Flammability: Combustible liquid
Vapor Pressure: 1.6 mmHg at 25°C
Vapor Density: >1 (air = 1)
Relative Density: 1.19 g/cm³ (20°C)
Solubility: Slightly soluble in water, soluble in organic solvents
Partition Coefficient (log Kow): 1.43
Auto-ignition Temperature: Not established
Decomposition Temperature: Not determined

10. Stability and Reactivity

Chemical Stability: Stable under normal conditions and recommended storage
Reactivity: May react with strong bases, amines, nucleophiles; sensitive to moisture
Hazardous Reactions: Releases corrosive hydrogen bromide upon decomposition
Incompatibilities: Strong oxidizers, reducing agents, strong bases, water
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen bromide

11. Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity: Oral LD50 (rat): approximately 650 mg/kg
Skin Corrosion/Irritation: Causes irritation, redness reported after exposure
Serious Eye Damage/Irritation: Causes eye irritation, risk of redness, tearing, damage
Respiratory Sensitization: Inhalation risk, coughing, shortness of breath possible
Long-term Effects: No reliable chronic toxicity data; extended exposure may lead to organ effects based on chemical class
Other Information: Symptoms may be delayed; monitor for chemical sensitivity

12. Ecological Information

Ecotoxicity: Harmful to aquatic organisms; may cause long-lasting adverse effects to aquatic environments
Persistence and Degradability: Not readily biodegradable, may persist in environment
Bioaccumulative Potential: Bioaccumulation unlikely due to low log Kow
Mobility in Soil: Moderately mobile; possible contamination of water sources if released
Other Adverse Effects: Avoid release to environment, precautions required for spill containment

13. Disposal Considerations

Safe Disposal Methods: Dispose of as hazardous waste in accordance with local, regional, national regulations
Contaminated Packaging: Dispose of used containers safely; decontaminate before recycling or reuse
Precautions for Disposal: Do not discharge into sewer or waterways
Recycling Information: Consult licensed waste disposal contractor

14. Transport Information

UN Number: 2810
UN Proper Shipping Name: Toxic liquids, organic, n.o.s. (Tert-Butyl Bromoacetate)
Transport Hazard Class: 6.1
Packing Group: III
Environmental Hazards: Harmful to aquatic environment, reportable quantity may apply
Transport Labels: Toxic (poison), environmentally hazardous substance
Special Precautions: Avoid spillage during handling and shipment; ship with emergency information

15. Regulatory Information

TSCA (US): Listed
REACH (EU): Registered substance, subject to restrictions on hazardous chemicals
OSHA: Considered hazardous according to OSHA Hazard Communication Standard
WHMIS (Canada): Classified as hazardous material
Other Regulatory Data: Refer to local, regional, and national regulations; check for restrictions on use and import; registration or notification may be mandatory in some countries
Labeling Requirements: Clearly label as hazardous, include safety data, provide SDS to downstream users